Low Temperature Chemistry

Lacamas Laboratories uses direct liquid nitrogen injection for low temperature reactions. Such reactions include the following:

  • Lithium halogen exchange
  • O-directed metallation
  • Transmetallation
  • Enolate chemistry (use of n-BuLi / LDA / LiHMD etc)
  • Low temperature crystallizations (for certain low melting materials)
  • Highly exothermic reactions –  the need for extreme cooling can sometimes be obviated by use of continuous flow.

formylation