Lacamas Laboratories uses direct liquid nitrogen injection for low temperature reactions. Such reactions include the following:
- Lithium halogen exchange
- O-directed metallation
- Enolate chemistry (use of n-BuLi / LDA / LiHMD etc)
- Low temperature crystallizations (for certain low melting materials)
- Highly exothermic reactions – the need for extreme cooling can sometimes be obviated by use of continuous flow.